Publications

Original Articles in Peer-Reviewed Journals

Title
Author(s)
Journal
Pub.
Year
SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis.

Canonigo-Balancio AJ, Fos C, Prod'homme T, Bécart S, Altman A.  J Immunol.  2009
Navigating the leukocyte signaling maze guided by Ariadne's thread.

Altman A, Koretzky GA, Tsoukas CD.  Nat Immunol.  2009
SWAP-70-like adapter of T cells: a novel Lck-regulated guanine nucleotide exchange factor coordinating actin cytoskeleton reorganization and Ca2+ signaling in T cells.

Bécart S, Altman A.  Immunol Rev.  2009
Does Def6 deficiency cause autoimmunity?

Altman A, Bécart S. Immunity
2009
Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells. Hundt M, Harada Y, De Giorgio L, Tanimura N, Zhang W, Altman A. J Immunol. 2009

PKCtheta is required for hemostasis and positive regulation of thrombin-induced platelet aggregation and alpha-granule secretion. 

Cohen S, Braiman A, Shubinsky G, Ohayon A, Altman A, Isakov N.
Biochem Biophys Res Commun. 2009

Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages. 

Mehta H, Glogauer M, Bécart S, Altman A, Coggeshall KM.
J Biol Chem.
2009

Tyrosine-phosphorylation-dependent translocation of the SLAT protein to the immunological synapse is required for NFAT transcription factor activation. 

Bécart S, Balancio AJ, Charvet C, Feau S, Sedwick CE, Altman A.
Immunity
2008

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.

Zarbock A, Abram CL, Hundt M, Altman A, Lowell CA, Ley K.
J Exp Med.
2008

PKCdelta acts upstream of SPAK in the activation of NKCC1 by hyperosmotic stress in human airway epithelial cells. 

Smith L, Smallwood N, Altman A, Liedtke CM.
J Biol Chem.
2008

SLAT regulates Th1 and Th2 inflammatory responses by controlling Ca2+/NFAT signaling.

Bécart S, Charvet C, Canonigo Balancio AJ, De Trez C, Tanaka Y, Duan W, Ware C, Croft M, Altman A.
J Clin Invest.
2007

Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Ctheta.

Melowic HR, Stahelin RV, Blatner NR, Tian W, Hayashi K, Altman A, Cho W. J Biol Chem.
2007

Protein kinase C theta (PKCtheta): a key player in T cell life and death. 

Hayashi K, Altman A.
Pharmacol Res.
2007

Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression. 

Charvet C, Canonigo AJ, Bécart S, Maurer U, Miletic AV, Swat W, Deckert M, Altman A.
J Immunol. 2006

Filamin A is required for T cell activation mediated by protein kinase C-theta.

Hayashi K, Altman A.
J Immunol.
2006

Protein kinase C-theta (PKCtheta): new perspectives on its functions in T cell biology.

Barouch-Bentov R, Altman A.
Adv Exp Med Biol.
2006

Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect.

Hundt M, Tabata H, Jeon MS, Hayashi K, Tanaka Y, Krishna R, De Giorgio L, Liu YC, Fukata M, Altman A.
Immunity.
2006

Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment.  

So T, Song J, Sugie K, Altman A, Croft M.
Proc Natl Acad Sci U S A.
2006

Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation. 

Nika K, Charvet C, Williams S, Tautz L, Bruckner S, Rahmouni S, Bottini N, Schoenberger SP, Baier G, Altman A, Mustelin T.
Mol Cell Biol.
2006

Protein kinase Ctheta controls Th1 cells in experimental autoimmune encephalomyelitis.

Salek-Ardakani S, So T, Halteman BS, Altman A, Croft M.
J Immunol.
2005

Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells.  

Barouch-Bentov R, Lemmens EE, Hu J, Janssen EM, Droin NM, Song J, Schoenberger SP, Altman A. J Immunol.
2005

Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice. 

Tanaka Y, So T, Lebedeva S, Croft M, Altman A.
Blood.
2005
Clustering of T cell ligands on artificial APC membranes influences T cell activation and protein kinase C theta translocation to the T cell plasma membrane.  Giannoni F, Barnett J, Bi K, Samodal R, Lanza P, Marchese P, Billetta R, Vita R, Klein MR, Prakken B, Kwok WW, Sercarz E, Altman A, Albani S.
J Immunol. 2005