Welcome to the 

Laboratory of Experimental Rheumatology

at the 

La Jolla Institute for Allergy and Immunology 

Return to the Bottini Faculty Page 

Principal Investigator: Nunzio Bottini, MD, PhD


Biosketch: Dr. Bottini obtained his MD and PhD from the University of Rome Tor Vergata, where he also completed his clinical internship and residency. He received postdoctoral research training in biochemistry and signal transduction at the Sanford-Burnham Medical Research Institute in La Jolla, and completed a clinical fellowship in Rheumatology at the University of California San Diego. Between 2005 and 2009 he held an Assistant Professor position at the Institute for Genetic Medicine of the University of Southern California. In May 2009 he was recruited to LJI where he is currently an Associate Professor in the Division of Cellular Biology. Since 2013, Dr. Bottini also holds an appointment as an Associate Professor of Medicine in the Division of Rheumatology, Allergy and Immunology of the University of California San Diego (http://raidivision.ucsd.edu/Faculty/Pages/nunzio-bottini.aspx).

Research Interest: The Bottini laboratory at LJI studies intracellular signaling pathways in cell types involved in human autoimmune connective tissue diseases, with particular emphasis on rheumatoid arthritis and systemic sclerosis. The laboratory studies the mechanism of action of signaling molecules encoded by human disease-predisposing genes and also analyzes signal transduction pathways in pathological specimens from patients. The goal is to dissect relevant intracellular pathways to design new methods for disease activity monitoring and to identify new treatment strategies.

The laboratory specializes in the study of a family of signaling enzymes called protein tyrosine phosphatases, which regulates phosphorylation of proteins on tyrosine residues.

The laboratory strongly emphasizes translational "bed to bench to bedside" research and collaborations with pharmaceutical companies are routinely sought to accelerate translation of laboratory findings into the clinic. 

Clinical Interest: Dr. Bottini treats patients on Thursday afternoons at the UCSD Hillcrest Rheumatology clinic (see http://doctors.ucsd.edu/Details/22359). He also attends on the UCSD Rheumatology Consult Service for one month/year.

Teaching Activity: Besides supervising postdoctoral trainees in the LJI laboratory, Dr. Bottini enjoys teaching medical students, Internal Medicine residents and Rheumatology Fellows at the UCSD School of Medicine.  

Personal Notes: Dr. Bottini lives in San Diego with his wife Angel, his daughter Livia, and a mischievous bunny called Pippo (see picture). In his free time he enjoys tending to roses, bike riding and running.