Publications

Original Articles in Peer-Reviewed Journals

Title
Author(s)
Journal
Pub.
Year
Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis.  Diaz-Gallo LM, Expino-Paisan L, Fransen K, Gomez-Garcia M, van Sommersen S, Cardena C, Rodrigo L, Mendoza JL, Taxonera C, Nieto A, Alcain G, Cueto I, Lopez-Nevot MA, Bottini N, Barclay ML, Crusis JB, van Bodegraven AA, Wijmenga C, Ponsioen CY, Gearry RB, Roberts RL, Weersma RK, Urcelay E, Merriman TR, Alizadeh BZ, Martin J.

Inflamm Bowel Dis.  2011
PEG-modified carbon nanatubes in biomedicine: current status and challenges ahead.
 		 Bottini M, Rosato N, Bottini N. Biomacromolecules.  2011
Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients.  Teruel M, Martin JE, Gonzalez-Juanatey C, Lopez-Mejias R, Miranda-Filloy JA, Blanco R, Balsa A, Pascual-Salcedo D, Rodrguez-Rodriguez L, Fernandez-Guiterrez B, Ortiz AM, Gonzalez-Alvaro I, Gomez-Vaquero C, Bottini N, Llorca J, Gonzalez-Gay MA, Martin J.

Arthritis Res Ther.  2011
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.  Stanford SM, Krishnamurthy D, Falk MN, Messina R, Debnath B, Li S, Liu T, Kazemi R, Dahl R, He YT, Yu XA, Chan AC, Zhang ZY, Barrios AM, Woods VL, Neamati N, Bottini N.

J Med Chem.  2011
The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples.

 Rodríguez-Rodríguez L, Taib WR, Topless R, Steer S, González-Escribano MF, Balsa A, Pascual-Salcedo D, González-Gay MA, Raya E, Fernandez-Gutierrez B, González-Álvaro I, Bottini N, Witte T, Viken MK, Coenen MJ, van Riel PL, Franke B, den Heijer M, Radstake TR, Wordsworth P, Lie BA, Merriman TR, Martín J. 

Arthritis Rheum 2011
Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue.

 Fiorillo E, Orrú V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N. 
J Biol Chem
2010
Carbon nanotube-based nanocarriers: the importance of keeping it clean.

 Delogu LG, Stanford SM, Santelli E, Magrini A, Bergamaschi A, Motamedchaboki K, Rosato N, Mustelin T, Bottini N, Bottini M.

 J Nanosci Nanotechnol 2010
A study of Adenosine-Deaminase genetic polymorphism in rheumatoid arthritis.

 Sebastiani GD, Bottini N, Greco E, Saccucci P, Canu G, Lucarelli P, Gloria-Bottini F, Fontana L. Int J Immunopathol Pharmacol
 2010
Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.

Stanford SM, Mustelin TM, Bottini N. Semin Immunopathol 2010
A study of three polymorphic sites of the ADA gene in children with type 1 diabetes mellitus.
Saccucci P, Meloni GF, Verrotti A, Borgiani P, D'Annibale F, Giannini C, Lucarelli P, Bottini N, Chiarelli F, Bottini E, Gloria-Bottini F.

 

J Pediatr Endocrinol Metab
 2010
Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase.

 Karver MR, Krishnamurthy D, Bottini N, Barrios AM. J Inorg Biochem
 2010
Type I Diabetes Genetics Consortium. rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype.

 Steck AK, Baschal EE, Jasinski JM, Boehm BO, Bottini N, Concannon P, Julier C, Morahan G, Noble JA, Polychronakos C, She JX, Eisenbarth GS; Type I Diabetes Genetics Consortium. Genes Immun
2009
Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes.

Karver MR, Krishnamurthy D, Kulkarni RA, Bottini N, Barrios AM. J Med Chem
 2009
Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population.

 		Lamsyah H, Rueda B, Baassi L, Elaouad R, Bottini N, Sadki K, Martin J. Tissue Antigens
 2009
Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans.

 		Shu YH, Hartiala J, Xiang AH, Trigo E, Lawrence JM, Allayee H, Buchanan TA, Bottini N, Watanabe RM. J Clin Endocrinol Metab
 2009
Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain.

Liu Y, Stanford SM, Jog SP, Fiorillo E, Orrú V, Comai L, Bottini N. Biochemistry
2009

Crystal structure Of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain: Insights Into Redox Regulation.

 Tsai SJ, Sen U, Zhao L, Greenleaf WB, Dasgupta J, Fiorillo E, Orrú V, Bottini N, Chen XS. Biochemistry
 2009
Conjugation of Antisense Oligonucleotides to PEGylated Carbon Nanotubes Enables Efficient Knockdown of PTPN22 in T Lymphocytes.

Delogu LG, Magrini A, Bergamaschi A, Rosato N, Dawson MI, Bottini N, Bottini M. Bioconjug Chem
 2009
A loss of function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus.
Orrú V, Tsai SJ, Rueda B, Fiorillo E, Stanford SM, Dasgupta J, Hartiala J, Zhao L, Ortego-Centeno N, D'Alfonso S; Italian Collaborative Group, Arnett FC, Wu H, Gonzalez-Gay MA, Tsao BP, Pons-Estel B, Alarcon-Riquelme ME, He Y, Zhang ZY, Allayee H, Chen XS, Martin J, Bottini N.

Hum Mol Genet  2009
Gold(I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study.

Krishnamurthy D, Karver MR, Fiorillo E, Orrú V, Stanford SM, Bottini N, Barrios AM. J Med Chem
2008
Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy.

Saccucci P, Del Duca E, Rapini N, Verrotti A, Piccinini S, Maccari A, Canu G, Angelini F, Fontana L, Giannini C, Chiarelli F, Manca Bitti ML, Bottini N.

Tissue Antigens
 2008
Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes.

Zoledziewska M, Perra C, Orrù V, Moi L, Frongia P, Congia M, Bottini N, Cucca F. Diabetes
 2008
Protein tyrosine phosphatase PTPN22 in human autoimmunity.

Vang T, Miletic AV, Bottini N, Mustelin T. Autoimmunity
 2007
Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function.

Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP.

J Exp Med
2005
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.


Vang T, Congia M, Macis MD, Musumeci L, Orrú V, Zavattari P, Nika K, Tautz L, Taskén K, Cucca F, Mustelin T, Bottini N.

Nat Genet 2005
Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease.

Wu H, Cantor RM, Graham DS, Lingren CM, Farwell L, Jager PL, Bottini N, Grossman JM, Wallace DJ, Hahn BH, Julkunen H, Hebert LA, Rovin BH, Birmingham DJ, Rioux JD, Yu CY, Kere J, Vyse TJ, Tsao BP. Arthritis Rheum
 2005
Low-molecular-weight protein tyrosine phosphatases of Bacillus subtilis.

 Musumeci L, Bongiorni C, Tautz L, Edwards RA, Osterman A, Perego M, Mustelin T, Bottini N.

J Bacteriol 2005
In vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqE.

 Mijakovic I, Musumeci L, Tautz L, Petranovic D, Edwards RA, Jensen PR, Mustelin T, Deutscher J, Bottini N.

 J Bacteriol
 2005
Protein tyrosine phosphatases and the immune response.

Mustelin T, Vang T, Bottini N.

 Nat Rev Immunol 2005
Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes.

Ladner MB, Bottini N, Valdes AM, Noble JA.

Hum Immunol
 2005
Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds.

Tautz L, Bruckner S, Sareth S, Alonso A, Bogetz J, Bottini N, Pellecchia M, Mustelin T.

 J Biol Chem
 2005
Control of vesicle fusion by a tyrosine phosphatase.

Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E, Wang X, Kruger J, Chow CW, Pellecchia M, Monosov E, Greer PA, Trimble W, Downey GP, Mustelin T.

 Nat Cell Biol 2004
Protein tyrosine phosphatases in the human genome.

Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T.

Cell
 2004
A functional variant of lymphoid tyrosine phosphatase is associated with type 1 diabetes.

Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, MacMurray J, Meloni GF, Lucarelli P, Pellecchia M, Eisenbarth GS, Comings D, Mustelin T.

 		Nat Genet 2004
Lck dephosphorylation at Y394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH.

Alonso A, Bottini N, Bruckner S, Rahmouni S, Williams S, Schoenberger SP, Mustelin T.

 J Biol Chem
 2004