Publications

Original Articles in Peer-Reviewed Journals

Title
Author(s)
Journal
Pub.
Year

Regulatory T-cell stability and plasticity in mucosal and systemic immune systems.

Murai M, Krause P, Cheroutre H, Kronenberg M.  Mucosal Immunol.  2010

Mucosal T cells in gut homeostasis and inflammation.

van Wijk F, Cheroutre H.  Expert Rev Clin Immunol.  2010 
The 2010 Midwinter Conference of Immunologists at Asilomar.

Schoenberger SP, Cheroutre H, Uittenbogaart C, Marshak-Rothstein A. Nat Immunol.  2010 

The many face-lifts of CD4 T helper cells.

Mucida D, Cheroutre H.  Adv Immunol.  2010
HIV vaccination: turning the spotlight on effector memory T cells as mucosal gatekeepers.

Cheroutre H.  F1000 Biol Reports.  2009
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis.

Murai M, Turovskaya O, Kim G, Madan R, Karp CL, Cheroutre H, Kronenberg M.
Nat Immunol. 2009
The importance of being earnestly selfish.

Cheroutre H, Mucida D, Lambolez F.  Nat Immunol.
2009
Intestinal T cells: Facing the mucosal immune dilemma with synergy and diversity.

van Wijk F, Cheroutre H.  Semin Immunol.  2009
Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naïve T cells.

Mucida D, Pino-Lagos K, Kim G, Nowak E, Benson MJ, Kronenberg M, Noelle RJ, Cheroutre H.  Immunity.
2009
More stories on Th17 cells.

Basso, A.S., Cheroutre, H. and Mucida, D.  Cell Res.  2009
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.

Grivennikov, S., Karin, E., Terzic, J., Mucida, D., Yu, G.Y., Vallabhapurapu, S., Scheller, J., Rose-John, S., Cheroutre, H., Eckmann, L., and Karin, M.  Cancer Cell.
2009
From the diet to the nucleus: Vitamin A and TGF-beta join efforts at the mucosal interface of the intestine.

Mucida, D., Park, Y. and Cheroutre, H.  Semin Immunol.  2009
Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease.

Olivares-Villagómez, D., Mendez-Fernandez, Y.V., Parekh, V.V., Lalani, S., Vincent, T.L., Cheroutre, H. and Van Kaer, L.  Proc Natl Acad Sci U.S.A.  2008
Naïve precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance.

Kotturi, M.F., Scott, I., Wolfe, T., Peters B., Sidney, J., Cheroutre, H., von Herrath, M.G., Buchmeier, M.J., Grey, H. and Sette, A.  J. Immunol.  2008
Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.

Lee, S.W., Park, Y., So, T., Kwon, B.S., Cheroutre, H., Mittler, R.S. and Croft, M.  Nat Immunol.  2008
Therapeutic potential of a fully human monoclonal antibody against influenza A virus M2 protein. Wang, R., Song, a., Levin, J., Dennis, D., Zhang, N.J., Yoshida, H., Koriazova, L., Madura, L., Shapiro, L., Matsumoto, A., Yoshida, H., Mikayama, T., Kubo, R.T., Sarawar, S., Cheroutre, H. and Kato, S.  Antiviral Res.  2008
The thymus chapter in the life of gut-specific intra epithelial lymphocytes.

Cheroutre, H. and Lambolez, F.  Curr Opin Immunol.  2008
Ultimately, it matters where, when and what they'll meet.

Cheroutre, H. Gastroenterology  2008
Doubting the TCR Coreceptor Function of CD8αα.

Cheroutre, H. and Lambolez, F.  Immunity  2008
TGFβ and Retinoic Acid Intersect in Immune-Regulation.

Mucida, D. and Cheroutre, H.  Cell Adhesion & Migration  2007
Reciprocal Th17 and regulatory T cell differentiation mediated by retinoic acid.

Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M. and Cheroutre, H.  Science  2007
Mouse TCRab+CD8aa Intraepithelial Lymphocytes Express Genes That Down-Regulate Their Antigen Reactivity and Suppress Immune Responses.

Denning TL, Granger SW, Mucida D, Graddy R, Leclercq G, Zhang W, Honey K, Rasmussen JP, Cheroutre H, Rudensky AY, Kronenberg M.  J. Immunol.  2007
Identification of Pre- and Postselection TCRαβ+ Intraepithelial Lymphocyte Precursors in the Thymus.

Gangadharan, D., Lambolez, F., Attinger, A., Wang-Zhu, Y., Sullivan, B.A. and Cheroutre, H.  Immunity  2006
Functional dichotomy between OX40 and 4-1BB in modulating effector CD8 T cell responses.

Lee, S.W., Park, Y., Song, A., Cheroutre, H., Kwon, B.S. and Croft, M.  J. Immunol.  2006
In IBD eight can come before four.

Cheroutre, H.
Gastroenterology  2006

Mucosal effector memory T cells: the other side of the coin.

Cheroutre, H. and Madakamutil, L.  Review, Cell Mol Life Sci.  2005
Mucosal T lymphocytes-peacekeepers and warriors. Cheroutre, H. and Kronenberg, M.  Review, Springer Seminars in Immunopathology  2005
IELs: enforcing law and order in the court of the intestinal epithelium.

Cheroutre, H.   Immunological Reviews  2005
Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8αα molecule.

Attinger, A., Devine, L., Wang-Zhu, Y., Martin, D., Wang, J-H., Reinherz, E.L., Kronenberg, M., Cheroutre, H. and Kavathas, P.  J. Immunol.  2005
The CD8 isoform CD8αα is not a functional homologue of the TCR co-receptor CD8αβ.

Gangadharan D, Cheroutre H.  Curr Opin Immunol.  2004
CD8αα-mediated survival and differentiation of CD8 memory T cell precursors.  Madakamutil LT, Christen U, Lena CJ, Wang-Zhu Y, Attinger A, Sundarrajan M, Ellmeier W, von Herrath MG, Jensen P, Littman DR, Cheroutre H.   Science
2004
Acquired and natural memory T cells join forces at the mucosal front line.

Cheroutre, H. and Madakamutil L.   Nat Rev Immunol.  2004
Starting at the beginning: new perspectives on the biology of mucosal T cells.

Cheroutre, H.  Ann Rev Immunol.  2004
NIK-dependent RelB activation defines a unique signaling pathway for the development of Vα14i NKT cells.
 
45. Elewaut, D., Shaikh, R.B., Hammond, K.J.L., DeWinter, H., Leishman, A.J., Sidobre, S., Turovskaya, O., Prigozy, T.I., Ma, L., Banks, T., Lo, D., Ware, C.F., Cheroutre, H. and Kronenberg, M.  J. Exp. Med.  2003
The crystal structure of a TL/CD8αα complex at 2.1 A resolution: implications for modulation of T cell activation and memory.
 
Liu, Y., Xiong, Y., Naidenko, O.V., Liu, J.H., Zhang, R., Joachimiak, A., Kronenberg, M., Cheroutre, H., Reinherz, E.L. and Wang, J.H.   Immunity
2003
Peptide-independent folding and CD8αα binding by the nonclassical class I molecule, thymic leukemia antigen.
 
Weber, D.A., Attinger, A., Kemball, C.C., Wigal, J.L., Pohl, J., Xiong, Y., Reinherz, E.L., Cheroutre, H., Kronenberg, M. and Jensen, P.E.  J. Immunol.  2002
Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.  Hoyer, K.K., French, S.W., Turner, D.E., Nguyen, M.T., Renard, M., Malone, C.S., Knoetig, S., Qi, C.F., Su, T.T., Cheroutre, H., Wall, R., Rawlings, D.J., Morse III, H.C. and Teitell, M.A.  Proc. Natl. Acad. Sci. U.S.A.  2002
The complementarity-determining region-like loops of CD8 alpha interact differently with beta 2-microglobulin of the class I molecules H-2Kb and thymic leukemia antigen, while similarly with their alpha 3 domains.
 
Devine, L., Rogozinski, L., Naidenko, O.V., Cheroutre, H. and Kavathas, P.B.  J. Immunol.  2002
Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice.  De Winter, H., Elewaut, D., Turovskaya, O., Huflejt, M., Shimeld, C., Hagenbaugh, A., Binder, S., Takahashi, I., Kronenberg, M. and Cheroutre, H.  Gastroenterology  2002
Precursors of functional MHC class I or class II restricted CD8αα+ T cells are positively selected in the thymus by agonist self-peptides.

Leishman, A.J., Gapin, L., Capone, M., Palmer, E., MacDonald, H.R., Kronenberg, M. and Cheroutre, H.
Immunity  2002
Over-expression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL-receptor deficient mice by altering T cell phenotpes and macrophage activation.

Pinderski, L.J., Fischbein, M.P., Subbanagounder, G., Fishbein, M.C., Kubo, N., Cheroutre, H., Curtiss, L.K., Berliner, J.A. and Boisvert, W.A.  Circulation Res.
2002
Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation and tissue destruction.

Shaikh, R., Santee, S., Granger, S.W., Butrovich, K., Cheung, T., Kronenberg, M., Ware, C.F. and Cheroutre, H.  J. Immunol.  2001
T cell responses modulated through interaction between CD8αα and the nonclassical MHC class I molecule, TL.  Leishman, A.J., Naidenko, O.V., Attinger, A., Koning, F., Lena C.J., Xiong, Y., Chang, H.C., Reinherz, E., Kronenberg, M. and Cheroutre, H.  Science
2001
Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis.
 
Shih, D.M., Xia, Y.R., Wang, X.P., Miller, E., Castellani, L.W., Subbanagounder, G., Cheroutre, H., Faull, K.F., Berliner, J.A., Witztum, J.L. and Lusis, A.J.  J. Biol. Chem.  2000
Membrane lymphotoxin is required for the development of different subpopulations of NK T cells.  Elewaut, D., Brossay, L., Santee, S.M., Naidenko, O.V., Burdin, N., De Winter, H., Matsuda, J., Ware, C.F., Cheroutre, H. and Kronenberg, M.  J. Immunol.  2000
Do mucosal T cells prevent intestinal inflammation?
 
Kronenberg, M. and Cheroutre, H.  Gastroenterology  2000
Cutting edge: TCR αβ+ CD8αα+ T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules.

Gapin, L., Cheroutre, H. and Kronenberg, M.
J. Immunol.
1999
Mucosal immunity and inflammation. II. The yin and yang of T cells in intestinal inflammation: pathogenic and protective roles in a mouse colitis model.

De Winter, H., Cheroutre, H. and Kronenberg, M.  Am. J. Physiol.  1999
T-cell production of an inducible interleukin-10 transgene provides limited protection from autoimmune diabetes.
 
Pauza, M.E., Neal H., Hagenbaugh, A., Cheroutre, H. and Lo, D.  Diabetes  1999
An opposite pattern of selection of a single T cell antigen receptor in the thymus and among intraepithelial lymphocytes.
 
Cruz, D., Sydora, B.C., Hetzel, K., Yakoub, G., Kronenberg, M. and Cheroutre, H.  J. Exp. Med.  1998

Transgenic mice expressing a truncated Peromyscus leucopus TNF-alpha gene manifest an arthritis resembling ankylosing spondylitis.

 

Crew, M.D., Effros, R.B., Walford, R.L., Zeller, E., Cheroutre, H. and Brahn, E.  J. Interferon Cytokine Res.  1998
Btk dosage determines sensitivity to B cell antigen receptor cross- linking.
 
Satterthwaite, A.B., Cheroutre, H., Khan, W.H., Sideras, P. and Witte, O.  Proc. Natl. Acad. Sci. U.S.A.  1997
Altered immune responses in IL-10 transgenic mice.
 
Hagenbaugh, A., Sharma, S., Dubinett, S.M., Wei, S.H.Y., Aranda, R., Cheroutre, H., Fowell, D., Binder, S., Tsao, B., Locksley, R.M., Moore, K.W. and Kronenberg, M.  J. Exp. Med.  1997
Lymphocyte-epithelial cross talk in the intestine: do nonclassical class I molecules have a big part in the dialogue.
 
Sydora, B.C., Aranda, R., Tangri, S., Holcombe, H.R., Camerini, V., Castano, A.R., Miller, J.E.W., Cardell, S., Huse, W.D., Peterson, P.A., Cheroutre, H. and Kronenberg, M.  Essentials in Mucosal Immunology  1996
Tap-independent selection of CD8+ intestinal intraepithelial lymphocytes.

Sydora, B.C., Brossay, L., Hagenbaugh, A., Kronenberg, M. and Cheroutre, H.
J. Immunol.  1996
Antigen-presenting function of the TL antigen and mouse CD1 molecules.

Cheroutre, H., Holcombe, H.R., Tangri, S., Castano, A.R., Teitell, M., Miller, J.E.W., Cardell, S., Benoist, C., Mathis, D., Huse, W.D., Peterson, P.A. and Kronenberg, M.  Immunological Rev.  1995
Nonclassical behavior of the thymus leukemia antigen: peptide transporter independent expression of a nonclassical class I molecule.

Holcombe, H.R., Castaño, A.R., Cheroutre, H., Teitell, M., Maher, J.K., Peterson, P.A. and Kronenberg, M.  J. Exp. Med.  1995
Structure and function of H-2 T (Tla) region class I MHC molecules. Teitell, M., Cheroutre, H., Panwala, C., Holcombe, H., Eghtesady, P. and Kronenberg, M.  Crit. Rev. Immunol.  1994
Antigen presenting function of nonclassical class I molecules.  Kronenberg, M. and Cheroutre, H.  Regulation of Antigen Processing and Presentation.  1994
The α3 domain of the Qa-2 molecule is defective for CD8 binding and CTL activation.  Teitell, M., Holcombe, H.R., Cheroutre, H., Aldrich, C.J., Stroynowski, I., Forman, J. and Kronenberg, M.
J. Exp. Med. 
1993
B cells are anergic in transgenic mice that express IgM anti-DNA antibodies.
 
Tsao, B.P., Chow, A., Cheroutre, H., Song, Y.W., McGrath, M.E. and Kronenberg, M.  Eur. J. Immunol.  1993
Expression of mouse Tla region class I genes in tissues enriched for gamma delta cells.

Eghtesady P, Brorson KA, Cheroutre H, Tigelaar RE, Hood L, Kronenberg M.  Immunogenetics  1993
Failed self-tolerance and autoimmunity in IgG anti-DNA transgenic mice.

Tsao, B.P., Ohnishi, K., Cheroutre, H., Mitchell, B., Teitell, M., Mixter, P., Kronenberg, M. and Hahn, B.P.  J. Immunol.  1992
Expression of the Thymus Leukemia antigen in mouse intestinal epithelium.

Hershberg, R.M., Eghtesady, P., Sydora, B.C., Brorson, K.A., Cheroutre, H., Modlin, R.L. and Kronenberg, M.  Proc. Natl. Acad. Sci. U.S.A.  1990

Analysis of a new class I gene mapping to the Hmt region of the mouse.

Brorson, K.A., Richards, S., Hunt, S.W., Cheroutre, H., Fischer Lindahl, K. and Hood, L.  Immunogenetics  1989
Comparison of exon 5 sequences from 35 class I genes of the BALB/c mouse.
 
Brorson, K.A., Hunt, S.W., Hunkapiller, T., Sun, H., Cheroutre, H., Nickerson, D.A. and Hood, L.  J. Exp. Med.  1989
Identification and expression of cDNA plasmids corresponding to Human Interferon-Gamma (IFN-γ) and Interleukin 2 (IL-2).
 
Devos, R., Cheroutre, H., Plaetinck, G. and Fiers, W.  Lymphokines  1987
Molecular cloning of human interleukin-2 cDNA and its expression in E. Coli.  Devos, R., Plaetinck, G., Cheroutre, H., Simons, G., Degrave, W., Tavernier, J., Remaut, E. and Fiers, W.  Nucleic Acids Res.  1983
Molecular cloning of human lymphokines.

Cheroutre, H., Devos, R., Plaetinck, G., Scahill, S., Degrave, W., Tavernier, J., Taya, Y. and Fiers, W.  Gene Expression  1983
Molecular-biological studies on human fibroblast interferon, immune interferon and interleukin-2 genes.

Fiers, W., Devos, R., Cheroutre, H., Degrave, W., Duerinck, F., Gheysen, D., Plaetinck, G., Remaut, E., Scahill, S., Simons, G., Stanssens, P., Tavernier, J. and Vander Heyden, J.
The Biology of the Interferon System  1983
Expression of human fibroblast and human immune interferon genes in homologous and heterologous cells.

Remaut, E., Derynck, R., Devos, R., Cheroutre, H., Content, J., Contreras, R., Degrave, W., Gheysen, D., Stanssens, P., Tavernier, J., Taya, Y., Van Heuverswyn, H. and Fiers, W.  Interaction of Translation and Transcriptional Controls in the Regulation of Gene Expression.  1982
Simple efficient in vitro synthesis of capped RNA useful for direct expression of cloned eukaryotic genes.
 
Contreras, R., Cheroutre, H., Degrave, W. and Fiers, W.  Nucleic Acids Res.  1982
Cloning and structure of the human immune interferon-gamma chromosomal gene.
 
Taya, Y., Devos, R., Tavernier, J., Cheroutre, H., Engler, G. and Fiers, W.  EMBO J.  1982 
The human fibroblast and the human immune interferon gene and their expression in homologous and heterologous cells.
 
Fiers, W., Remaut, E., Devos, R., Cheroutre, H., Contreras, R., Gheysen, D., Degrave, W., Stanssens, P., Tavernier, J., Taya, Y. and Content, J.  Phil. Trans. R. Soc. London B.
1982 
Molecular cloning of human immune interferon cDNA and its expression in eucaryotic cells.
 
Devos, R., Cheroutre, H., Taya, Y., Degrave, W., Van Heuverswyn, H. and Fiers, W.  Nucleic Acids Res.  1982 
Isolation and characterization of IFN-gamma and mRNA derived from mitogen-induced human splenocytes.
 
Devos, R., Cheroutre, H., Taya, Y. and Fiers, W.  J. Interferon Res.  1982 
A simple apparatus for injection of nanoliter quantities into Xenopus laevis oocytes.
 
Contreras, R., Cheroutre, H. and Fiers, W.  Anal. Biochem.  1981