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“It would be a wonderful thing if we could stop terrible diseases before they have a chance to do any damage.”
Hilde Cheroutre, Ph.D.
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Autoimmune Research
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biography

cell-bullet1.jpg "Rather than figuring out how to treat disease, I’d like to understand how to prevent it.  It would be a wonderful thing if we could stop terrible diseases before they have a chance to do any damage."  – Hilde Cheroutre, Ph.D.

Dr. Cheroutre joined LIAI in 1998 and is a Member in the Division of Developmental Immunology. Dr. Cheroutre's research focuses on the selection, regulation and activation of different classes of T cells, such as regulatory and memory T cells.

Dr. Cheroutre received her Licentiate in Sciences from the State University of Ghent in Belgium in 1978. She received her Ph.D. from the same university in 1984, earning highest honors. That same year, Dr. Cheroutre began her postdoctoral work at the California Institute of Technology in Pasadena. In 1988, Dr. Cheroutre began a three-year stint working in the lab of Mitchell Kronenberg, Ph.D., current President and Scientific Director of LIAI, in the Department of Microbiology and Immunology at the University of California, Los Angeles. From 1991 to 1997, Dr. Cheroutre was co-director of UCLA's Transgenic Mouse Facility.

Dr. Cheroutre has been awarded the NATO postdoctoral fellowship twice, as well as the Markey Foundation Postdoctoral Fellowship and the Cancer Research Coordinating Committee Fellowship from the State of California.

research focus

cell-bullet2.jpg Hilde Cheroutre, Ph.D., and her team are studying the development, function, and regulation of white blood cells, a type of T lymphocytes. The laboratory is investigating how the immune system provides protection at "interfaces," or places where the outside world comes in contact with the inside of the body, such as skin, lungs, mouth, and the largest surface of all, the intestine.

Studying how the immune system works in the intestine is of particular interest because the immune system has to be able to distinguish pathogenic antigens from harmless food peptides and bacteria. The laboratory is investigating how the immune system succeeds in differentiating between the two and what causes the system to fail, allowing the antigens to invade the body.

The lab's research has been expanded to studying immune memory cells that resist re-entering pathogens or cancer cells. Tumor cells produce tumor antigens, which are cell surface proteins that differ from the proteins expressed by the surrounding normal cells. White blood cells recognize and destroy these transformed cells. Some of these tumor-fighting white blood cells go on to become immune memory cells. These are long-lived cells that activate immediately when they re-encounter tumor antigens, in the case of metastasis or re-occurrence of the tumor.

Understanding the function of immune memory T cells will help in the development and improvement of effective vaccines. At the same time, the ability to specifically eliminate these cells is a key requirement in the therapeutic intervention against autoimmune diseases and the rejection and/or destruction of host tissue following transplantation.

selected publications

cell-bullet3.jpgInterleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol. 2009

The importance of being earnestly selfish. Nat Immunol. 2009

Intestinal T cells: Facing the mucosal immune dilemma with synergy and diversity. Semin Immunol. 2009 

Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naïve T cells. Immunity. 2009

More stories on Th17 cells. Cell Res. 2009 

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 2009 

From the diet to the nucleus: Vitamin A and TGF-beta join efforts at the mucosal interface of the intestine. Semin Immunol. 2009

Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease. Proc Natl Acad Sci U.S.A. 2008

Naïve precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance. J. Immunol. 2008

Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. Nat Immunol. 2008

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The link above may include papers by scientists with the same or similar name.

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AWARDS AND HONORS
  • 2009 NIH Director's Pioneer Award
  • NATO Postdoctoral Fellowship
  • Markey Foundation Postdoctoral Fellowship
  • Cancer Research Coordinating Committee Fellowship from the State of California
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