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“It's a perennial race between new infectious diseases arising and society reacting to them, understanding them and defeating them. ”
Alessandro Sette, Ph.D.
Head and Member
Center for Infectious Disease; Allergy & Asthma Research
Contact
biography

cell-bullet1.jpg“New infectious agents originate all the time dating back to the plague in the siege of Athens in the 7th Century to the endemic flu in 1918 that killed 20 million people. For medical science, it’s a perennial race between new infectious diseases coming up and society reacting to them, understanding them and ultimately defeating them.” – Alessandro Sette, Ph.D.

Dr. Sette started at LIAI in 2002 as the Head of the Initiative for Emerging Diseases and Biodefense. In 2003 he became the Head of the Division of Translational Immunology. At LIAI, Dr. Sette's research focuses on the identification of epitopes, working to understand how vaccines should be constructed. The team's work is heavily focused on emerging disease threats or bioterror threats, such as SARS, arena viruses, smallpox and flu viruses. Dr. Sette's group is also leading an effort to bring a premier collaboration resource to the scientific community. The NIAID has awarded Dr. Sette a long-term contract to design and produce a national Immune Epitope Database (IEDB) to aide in the acceleration of vaccine-development on a global scale.

Dr. Sette received his degree in Biological Sciences from the University of Roma, Laboratory of Pathology in 1984. In 1984, Dr. Sette was a Postdoctoral Fellow in the same laboratory. From 1986-1988, he joined The National Jewish Center for Immunology and Respiratory Medicine in Denver, in the USA as a post-doctoral fellow.

In 2002, Dr. Sette was named Adjunct Professor in the Department of Experimental Medicine at the Scripps Research Institute, where he is also Scientific Director of the Rheumatic Diseases Core Center since 2004. In 2003 he was named Adjunct Professor in the department of Medicine at the University of California, San Diego.

Dr. Sette is a member of numerous grant review panels and a reviewer for many scientific publications. He is also a member of the editorial advisory board for Immunogenetics, Human Immunology, Current Pharmaceutical Biotechnology, Current Drugs, and Tissue Antigens.
research focus
cell-bullet2.jpgAlessandro Sette, Dr. Biol.Sc., and his laboratory study ways to fight diseases by understanding the immune response, measuring immune activity, and developing disease intervention strategies against a number of new and emerging infectious diseases. These include Influenza, arena viruses, a family of viruses responsible for hemorrhagic fever and meningitis, Severe Acute Respiratory Syndrome (SARS) as well as diseases of renewed interest, such as smallpox, because of the growing threat of bioterrorism. The laboratory is defining in chemical terms what murine, non-human primate and human immune system recognizes and uses this knowledge to measure and understand anti-pathogen immune responses. This approach is helping unlock the mysteries of how the body successfully battles infection, and conversely, how pathogens escape the immune system, causing the individual to succumb to disease. Form this data, Sette and his team believe their research will lead to development of new therapeutic and prophylactic approaches to fighting infectious diseases.

A major focus of the Sette's group is also the design and population of the Immune Epitope Database, developed under a NIAID contract. The database allows researchers around the world to quickly access key information on the way the body responds to disease-causing agents, especially those that are responsible for emerging infectious diseases, or that are part of potential bioterrorist threats. By allowing researchers to share and analyze data in this unprecedented manner, the database provides an important tool for accelerating the development and improvement of vaccines.
selected publications

cell-bullet3.jpgMeta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues. Parasite Immunol. 2009

Correlates of protection efficacy induced by vaccinia virus-specific CD8(+) T-cell epitopes in the murine intranasal challenge model. Eur J Immunol. 2009

HLA class I supertypes: a revised and updated classification. BMC Immunol. 2008

Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. Immunity. 2008  

Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserve. J Immunol. 2008

Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance. J Immunol. 2008

Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses. J Virol. 2008  

Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes. Proc Natl Acad Sci U S A. 2008  

Immunomic Analysis of the Repertoire of T cell Specificities for Influenza A Virus in Humans. J Virol. 2008 

Characterization of the peptide-binding specificity of the chimpanzee class I alleles A 0301 and A 0401 using a combinatorial peptide library. Immunogenetics. 2007

Immune epitope mapping in the post-genomic era: lessons for vaccine development. Curr Opin Immunol. 2007

Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection. Nat Med. 2007 

Integrating epitope data into the emerging web of biomedical knowledge resources. Nat Rev Immunol. 2007

Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses. J Immunol. 2007

Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes. J Immunol. 2007

The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus. J Virol. 2007

Ab and T cell epitopes of influenza A virus, knowledge and opportunities. Proc Natl Acad Sci U S A. 2007

A quantitative analysis of the variables affecting the repertoire of T cell specificities recognized after vaccinia virus infection. J Immunol. 2007

A community resource benchmarking predictions of peptide binding to MHC-I molecules. PLoS Comput Biol. 2006

A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus. Nat Biotechnol. 2006

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The link above may include papers by scientists with the same or similar name.

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AWARDS AND HONORS
  • International Immunomics and Immmunogenics Society Award, 2006
  • Named Adjunct Professor in the Department of Medicine at the University of California, San Diego, 2003
  • Named Adjunct Professor in the Department of Experimental Medicine at the Scripps Research Institute, 2002
  • ISI highly cited investigator (top 100 in the Immunology category over the 1981-2000. Period), with over 11,000 Citation Index citations, 2001
  • American Liver Foundation Award for Biotechnology Companies, 2000
  • Member of the Kriegler Lecture and Award Selection Committee, 1998
  • 51st Oregon State University Biological Colloquium Award, 1990
  • American Association of Immunologists Investigator Award, 1995
  • Member of A. Geluk Ph.D. thesis graduating committee, University of Leiden, The Netherlands, 2005

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