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Patrick Hogan, Ph.D., studies cells at the nano level -
seeking to understand how protein-protein interactions on the submicroscopic
scale can have gargantuan impacts on human health and disease. "My laboratory is interested in the
processes by which proteins interact with each other and with DNA to turn on
genes in the nucleus. That's the
whole secret of how T cells work," he said, referring to the body's
infection-fighting white blood cells.
"The interactions we study are subtle but can be the key to human
health and disease." Dr.
Hogan researches how calcium entry into T cells turns on the genes that are
necessary to fight infections and cancers. "This flows from my earlier work in neurobiology,"
he said, "where we tried to understand how pain sensory neurons are
activated. That was my
apprenticeship in how calcium and other ions enter cells, and how cells
perceive and respond to signals."
His laboratory made a landmark discovery in 2006, when they studied a
protein, ORAI1, that was mutated in two children with immune deficiency, making
the children unusually susceptible to life-threatening infections. Dr. Hogan related the immune deficiency
directly to calcium by showing that ORAI1 forms the pore of the calcium entry
channel in T cells. "The
hopeful lesson we take from these immunodeficient patients is that it may be
possible to develop new therapies for transplant rejection and autoimmune
disorders by targeting the calcium channel," he said.