Publications

Original Articles in Peer-Reviewed Journals

Title
Author(s)
Journal
Pub.
Year
Intestinal Microbes Affect Phenotypes and Functions of Invariant Natural Killer T cells in Mice.

Wingender G, Stepniak D, Krebs P, Lin L, McBride S, Wei B, Braun J, Mazmanian SK, Kronenberg M.
Gastroenterology.
2012
Neutrophilic granulocytes modulate invariant NKT cell function in mice and humans.

Wingender G, Hiss M, Engel I, Peukert K, Ley K, Haller H, Kronenberg M, von Vietinghoff S.
J Immunol.
2012
Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells.

Pei B, Vela JL, Zajonc D, Kronenberg M.
Curr Opin Immunol.
2012
Making memory at birth: understanding the differentiation of natural killer T cells.

Engel I, Kronenberg M.
Chem Biol.
2011
Glycolipids that elicit IFN-γ-biased responses from natural killer T cells.

Tyznik AJ, Farber E, Girardi E, Birkholz A, Li Y, Chitale S, So R, Arora P, Khurana A, Wang J, Porcelli SA, Zajonc DM, Kronenberg M, Howell AR.
PLoS Biol.
2011
Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells.

Girardi E, Yu ED, Li Y, Tarumoto N, Pei B, Wang J, Illarionov P, Kinjo Y, Kronenberg M, Zajonc DM.
Nat Immunol.
2011
Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule.

Huang Y, Park Y, Wang-Zhu Y, Larange A, Arens R, Bernardo I, Olivares-Villagómez D, Herndler-Brandstetter D, Abraham N, Grubeck-Loebenstein B, Schoenberger SP, Van Kaer L, Kronenberg M, Teitell MA, Cheroutre H.

Proc Natl Acad Sci U.S.A.
2011
Cooling the fires of inflammation.

Kim G, Kronenberg M.
 
Nat Immunol.
2011
Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria.

Kinjo Y, Illarionov P, Vela JL, Pei B, Girardi E, Li X, Li Y, Imamura M, Kaneko Y, Okawara A, Miyazaki Y, Gómez-Velasco A, Rogers P, Dahesh S, Uchiyama S, Khurana A, Kawahara K, Yesilkaya H, Andrew PW, Wong CH, Kawakami K, Nizet V, Besra GS, Tsuji M, Zajonc DM, Kronenberg M.
J Exp Med.
2011
Invariant NKT cells are required for airway inflammation induced by environmental antigens.
 
Wingender G, Rogers P, Batzer G, Lee MS, Bai D, Pei B, Khurana A, Kronenberg M, Horner AA.
J Exp Med.
2011
Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection.

Kisseleva T, von Köckritz-Blickwede M, Reichart D, McGillvray SM, Wingender G, Kronenberg M, Glass CK, Nizet V, Brenner DA.  J Mol Med.   2011
Hepatic Stellate Cells Function as Regulatory Bystanders.

Ichikawa S, Mucida D, Tyznik A, Kronenberg M, Cheroutre H.  J Immunol.
 2011
Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids.

Pei B, Speak AO, Shepherd D, Butters T, Cerundolo V, Platt FM, Kronenberg M.
J Immunol.   2011
Regulation of inflammation, autoimmunity, and infection immunity by HVEM-BTLA signaling.

Shui JW, Steinberg MW, Kronenberg M.  J Leukoc Biol.   2011
The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode.

Li Y, Girardi E, Wang J, Yu ED, Painter GF, Kronenberg M, Zajonc DM.  J Exp Med.   2010
Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency.

Wingender G, Krebs P, Beutler B, Kronenberg M.  J Immunol.   2010
Regulatory T-cell stability and plasticity in mucosal and systemic immune systems.

Murai M, Krause P, Cheroutre H, Kronenberg M.  Mucosal Immunol.   2010
Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection.

Engel I, Hammond K, Sullivan BA, He X, Taniuchi I, Kappes D, Kronenberg M.  J Exp Med.   2010
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model.

Amu S, Saunders SP, Kronenberg M, Mangan NE, Atzberger A, Fallon PG.  J Allergy Clin Immunol.   2010
The role of invariant NKT cells at the interface of innate and adaptive immunity.

Cerundolo V, Kronenberg M.  Semin Immunol.   2010
Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.

Barnes MJ, Aksoylar H, Krebs P, Bourdeau T, Arnold CN, Xia Y, Khovananth K, Engel I, Sovath S, Lampe K, Laws E, Saunders A, Butcher GW, Kronenberg M, Steinbrecher K, Hildeman D, Grimes HL, Beutler B, Hoebe K.  J Immunol.
 2010
A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity.

Lombardi V, Stock P, Singh AK, Kerzerho J, Yang W, Sullivan BA, Li X, Shiratsuchi T, Hnatiuk NE, Howell AR, Yu KO, Porcelli SA, Tsuji M, Kronenberg M, Wilson SB, Akbari O.  J Immunol.
 2010
Commensal microbiota and CD8+ T cells shape the formation of invariant NKT cells.

Wei B, Wingender G, Fujiwara D, Chen DY, McPherson M, Brewer S, Borneman J, Kronenberg M, Braun J.  J Immunol.
 2010
Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells.

Wang J, Li Y, Kinjo Y, Mac TT, Gibson D, Painter GF, Kronenberg M, Zajonc DM.  Proc Natl Acad Sci U S A.   2010
Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells.

Sullivan BA, Nagarajan NA, Wingender G, Wang J, Scott I, Tsuji M, Franck RW, Porcelli SA, Zajonc DM, Kronenberg M.  J Immunol.   2010
Carbohydrate Moieties as Vaccine Candidates: meeting summary.

Lucas AH, Rittenhouse-Olson K, Kronenberg M, Apicella MA, Wang D, Schreiber JR, Taylor CE.  Vaccine.  2010
T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment.
 
Cheung TC, Oborne LM, Steinberg MW, Macauley MG, Fukuyama S, Sanjo H, D'Souza C, Norris PS, Pfeffer K, Murphy KM, Kronenberg M, Spear PG, Ware CF.  J Immunol.  2009
Transcriptional regulator Id2 controls survival of hepatic NKT cells.

Monticelli LA, Yang Y, Knell J, D'Cruz LM, Cannarile MA, Engel I, Kronenberg M, Goldrath AW.  Proc Natl Acad Sci U S A.  2009
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.

Kojo S, Elly C, Harada Y, Langdon WY, Kronenberg M, Liu YC.  Proc Natl Acad Sci U S A.  2009
The Roles of 3' and 4' Hydroxy Groups in alpha-Galactosylceramide Stimulation of Invariant Natural Killer T Cells.

Xia C, Zhang W, Zhang Y, Chen W, Nadas J, Severin R, Woodward R, Wang B, Wang X, Kronenberg M, Wang PG.
ChemMedChem. 2009
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis.

Murai, M., Turovskaya, O., Kim, G., Madan, R., Karp, C.L., Cheroutre, H., and Kronenberg M. 
Nat Immunol. 2009
Innate-like recognition of microbes by invariant natural killer T cells. 

Kronenberg M, Kinjo Y.  
Curr Opin Immunol.
2009
Carbohydrate specificity of the recognition of diverse glycolipids by natural killer T cells.

Zajonc DM, Kronenberg M.
Immunol Rev.
2009
NKT cells turn 10. 

Burrows PD, Kronenberg M, Taniguchi M.
Nat Immunol.
2009
Synthesis and evaluation of 3''- and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000.

Raju R, Castillo BF, Richardson SK, Thakur M, Severins R, Kronenberg M, Howell AR.
Bioorg Med Chem Lett.
2009
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.

Steinberg MW, Shui JW, Ware CF, Kronenberg M.
Semin Immunopathol.
2009
Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naive T cells.

Mucida D, Pino-Lagos K, Kim G, Nowak E, Benson MJ, Kronenberg M, Noelle RJ, Cheroutre H.
Immunity
2009
Unconventional ligand activation of herpesvirus entry mediator signals cell survival.  Cheung TC, Steinberg MW, Oborne LM, Macauley MG, Fukuyama S, Sanjo H, D'Souza C, Norris PS, Pfeffer K, Murphy KM, Kronenberg M, Spear PG, Ware CF.
Proc Natl Acad Sci U.S.A.
2009
NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi. Tupin E, Benhnia MR, Kinjo Y, Patsey R, Lena CJ, Haller MC, Caimano MJ, Imamura M, Wong CH, Crotty S, Radolf JD, Sellati TJ, Kronenberg M.
Proc Natl Acad Sci U.S.A.
2008

Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis.

Chuang YH, Lian ZX, Yang GX, Shu SA, Moritoki Y, Ridgway WM, Ansari AA, Kronenberg M, Flavell RA, Gao B, Gershwin ME.
Hepatology.
2008

Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation.


Kim G, Turovskaya O, Levin M, Byrne FR, Whoriskey JS, McCabe JG, Kronenberg M.
J Immunol.
2008
Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-γ. production and dampening of the adaptive Th1 and Th17 responses.

Grajewski RS, Hansen AM, Agarwal RK, Kronenberg M, Sidobre S, Su SB, Silver PB, Tsuji M, Franck RW, Lawton AP, Chan CC, Caspi RR.
J Immunol.
2008
Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals.

Tyznik AJ, Tupin E, Nagarajan NA, Her MJ, Benedict CA, Kronenberg M.
J Immunol.
2008

RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis.

Turovskaya O, Foell D, Sinha P, Vogl T, Newlin R, Nayak J, Nguyen M, Olsson A, Nawroth PP, Bierhaus A, Varki N, Kronenberg M, Freeze HH, Srikrishna G.
Carcinogenesis.
2008
Natural sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells.
Kinjo Y, Pei B, Bufali S, Raju R, Richardson SK, Imamura M, Fujio M, Wu D, Khurana A, Kawahara K, Wong CH, Howell AR, Seeberger PH, Kronenberg M.
Chem Biol.
2008
Acid test: lipid antigens get into the groove.

Kronenberg M, Sullivan BA.
Immunity.
2008
A crucial role for HVEM and BTLA in preventing intestinal inflammation.
Steinberg MW, Turovskaya O, Shaikh RB, Kim G, McCole DF, Pfeffer K, Murphy KM, Ware CF, Kronenberg M.
J Exp Med.
2008

Cutting edge: Activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids.

 

Velázquez P, Cameron TO, Kinjo Y, Nagarajan N, Kronenberg M, Dustin ML.
J Immunol.
2008
Role of NKT cells in the digestive system, IV.  The role of canonical natural killer T cells in mucosal immunity and inflammation.

Wingender G, Kronenberg M.
Am J Physiol Gastrointest Liver Physiol.
2008
CD1 mediated T cell recognition of glycolipids. Zajonc DM, Kronenberg M.
Curr Opin Struct Biol.
2007
Reciprocal Th-17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid.

Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., and Cheroutre H. 
Science
2007
TCR-mediated recognition of glycolipid CD1 complexes.

Sullivan BA, Kronenberg M.
Curr Top Microbiol Immunol.
2007
Paradoxical effect of reduced costimulation in T cell-mediated colitis.

Kim G, Levin M, Schoenberger SP, Sharpe A, Kronenberg M.
J Immunol.
2007
Natural killer T cells: Know thyself. Kronenberg, M., and Gapin, L.  Proc Natl Acad Sci USA  2007
Mouse TCRαβ+ CD8αα Intraepithelial Lymphocytes Express Genes That Down-Regulate Their Antigen Reactivity and Suppress Immune Responses.

Denning, T. L., Granger, S., Mucida, D., Graddy, R., Leclercq, G., Zhang, W., Honey, K., Rasmussen, J.P., Cheroutre, H., Rudensky, A.Y, and Kronenberg M.  J Immunol.
2007
Invariant NKT cells amplify the innate immune response to lipopolysaccharide.

Nagarajan, N. A., and Kronenberg, M.  J Immunol.
2007
On the road: progress in finding the unique pathway of invariant NKT cell differentiation.
 
Kronenberg, M., and Engel I.  Curr Opinion Immunol.  2007
Frontline T cells: γδ T cells and intraepithelial lymphocytes.

Kronenberg, M. and Havran, W.
Immunological Reviews  2007
Thymic differentiation of TCRαβ CD8αα+ IELs.

Lambolez, F., Kronenberg, M., and Cheroutre, H.  Immunological Reviews
2007
Activation of natural killer T cells by glycolipids.

Tupin, E., and Kronenberg, M.  Methods Enzymology  2006
Invariant natural killer cells in the response to bacteria: the advent of specific antigens.

Wingender, G., and Kronenberg, M.  Future Microbiology  2006
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Kinjo, Y., Tupin, E., Wu, D., Fujio, M., Garcia-Navarro, R., Benhnia, M.R., Zajonc, D.M., Ben-Menachem, G., Ainge, G.D., Painter, G.F., Khurana, A., Hoebe, K., Behar, S.M., Beutler, B., Wilson, I.A., Tsuji, M., Sellati, T.J., Wong, C.-H., and Kronenberg, M.   Nat Immunol  2006
A unique lymphotoxin {alpha}beta-dependent pathway regulates thymic emigration of V{alpha}14 invariant natural killer T cells.

Franki, A.S., Van Beneden, K., Dewint, P., Hammond, K.J., Lambrecht, S., Leclercq, G., Kronenberg, M., Deforce, D., and Elewaut, D.  Proc Natl Acad Sci U.S.A.  2006
Elevated Serum Anti-I2 and Anti-OmpW Antibody Levels in Children With IBD. Iltanen, S,, Tervo, L., Halttunen, T., Wei, B., Braun, J., Rantala, I., Honkanen, T., Kronenberg, M., Cheroutre, H., Turovskaya, O., Autio, V., and Ashorn, M.  Inflamm Bowel Dis.  2006
Design of natural killer T cell activators: Structure and function of a microbial glycosphingolipid bound to mouse CD1d.

Wu, D., Zajonc, D.M., Fujio, M., Sullivan, B.A., Kinjo, Y., Kronenberg, M., Wilson, I.A., and Wong C.H.  Proc Natl Acad Sci U.S.A. 2006
Immediate antigen-specific effector functions by TCR-transgenic CD8(+) NKT cells. Wingender, G., Berg, M., Jungerkes, F., Diehl, L., Sullivan, B.A., Kronenberg, M., Limmer, A., and Knolle, P.A.  Eur J Immunol. 2006
Carboxylated glycans mediate colitis through activation of NF-kappa B. Srikrishna, G., Turovskaya, O., Shaikh, R., Newlin, R., Foell, D., Murch, S., Kronenberg, M., and Freeze, H.H.  J Immunol.
2005
Vα14i NKT cells are innate lymphocytes that participate in the immune response to diverse microbes. Kinjo, Y. and Kronenberg, M.  J Clin Immunol.  2005
Synthesis and Evaluation of Sphinganine Analogues of KRN7000 and OCH. Ndonye, R.M., Izmirian, D.P., Dunn, M.F., Yu, K.O., Porcelli, S.A., Khurana, A., Kronenberg M., Richardson, S.K., and Howell AR.  J Org Chem.  2005
Activation or anergy: NKT cells are stunned by alpha-galactosylceramide. 

Sullivan, B.A. and Kronenberg, M.  J Clin Invest.  2005
Infection, Autoimmunity, and Glycolipids: T Cells Detect Microbes through Self-Recognition.

Kronenberg M., and Kinjo Y.  Immunity
2005
Crystal structure of mouse CD1d bound to the self ligand phosphatidyl-choline: a molecular basis for NKT cell activation.

Giabbai, B., Sidobre, S., Crispin, M.D., Sanchez-Ruiz, Y., Bachi, A., Kronenberg, M., Wilson, I.A., and Degano, M.  J Immunol.
2005
CD1 and MHC II find different means to the same end.

Sullivan, B.A., *Nagarajan, N.A., and Kronenberg, M.  Trends Immunol.  2005
Mucosal T lymphocytes-peacekeepers and warriors.

Cheroutre H, Kronenberg M.  Springer Semin Immunopathol.  2005
Regulation of immunity by self-reactive T cells.

Kronenberg M, and Rudensky A.  Nature
2005
Cutting Edge: CD4+CD25+ Regulatory T Cells Impaired for Intestinal Homing Can Prevent Colitis.

Denning, T.L., Kim, G., and Kronenberg, M.  J Immunol.
2005
Molecular Basis for the High Affinity Interaction between the Thymic Leukemia Antigen and the CD8αα Molecule.

Attinger, A., Devine, L., Wang-Zhu, Y., Martin, D., Wang, J.-h., Reinherz, E.L., Kronenberg, M., Cheroutre, H., and Kavathas, P.  J Immunol.
2005
The Mouse CD1d cytoplasmic tail mediates CD1d trafficking and antigen presentation by adaptor protein 3-dependent and independent mechanisms.

Lawton, A.P., Prigozy, T.I., Brossay, L., Pei, B., Khurana, A., Martin, D., Zhu, T., Späte, K., Ozga, M. Hönig, S., Bakke, O., and Kronenberg, M.  J Immunol.
2005
Recognition of bacterial glycosphingolipids by natural killer T cells. Kinjo, Y., Wu, D., Kim, G., Xing, G.-W., Poles, M.A., Ho, D.D., Tsuji, M., Kawahara, K., Wong, C.-H., and Kronenberg, M. Nature 2005
Toward an Understanding of NKT Cell Biology: Progress and Paradoxes.

Kronenberg M.  Ann. Rev Immunol.  2005
Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells. Wu, D., Xing, G.-W., Poles, M.A., Horowitz, A., Kinjo, Y., Sullivan, B., Bodmer-Narkevitch, V., Plettenburg, O., Kronenberg, M., Tsuji, M., Ho, D.D., and Wong C.-H.  Proc Natl Acad Sci.  2005
Going both ways: immune regulation via CD1d- dependent NKT cells.

Godfrey D.I., Kronenberg M.  J Clin Invest.  2004
The TCR expressed by Vα14i NKT cells has a unique mode of glycosphingolipid antigen recognition. Sidobre, S., Hammond, K.J.L., Bénazet-Sidobre, L., Maltsev, S.D., Richardson, S.K., Ndonye, R., Howell, A., Sakai, T., Besra, G.S., Porcelli, S.A., and Kronenberg, M.  Proc Natl Acad Sci U.S.A. 2004
The Third Way: pathways of antigen processing and presentation by CD1.   Lawton, A.P. and Kronenberg, M. Immunology and Cell Biology 2004