Publications

Original Articles in Peer-Reviewed Journals

Title
Author(s)
Journal
Pub.
Year
Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes.

Greenbaum, J., Sidney, J., Chung, J., Brander, C., Peters, B., and Sette, A.
 Immunogenetics.  2011
A model for collaborative curation, the IEDB and CHEBI curation of non-peptidic epitopes.

Vita, R.J., Peters, B., Josephs, Z., de Matos, R., Ennis, M., Turner, S., Steinbeck, C., Seymour, E., Zarebski, L., and Sette, A.  Immunome Res.  2011
Functional analysis of frequently expressed Chinese rhesus macaque MHC class I molecules Mamu-A*02601 and Mamu-B*08301 reveal HLA-A2 and HLA-A3 supertypic specificities.

Southwood, S., Solomon, C., Hoof, I., Rudersdorf, R., Sidney, J., Peters, B., Wahl, A., Hawkins, O., Hildebrand, W., Mothe, B.R., and Sette, A.  Immunogenics.
 2010
Divergent motifs but overlapping binding repertoires of six HLA-DQ molecules frequently expressed in the worldwide human population.

Sidney J, Steen A, Moore C, Ngo S, Chung J, Peters B, Sette A.   J Immunol.
 2010
Molecular determinants of T cell epitope recognition to the common Timothy grass allergen.
 

Oseroff C, Sidney J, Kotturi MF, Kolla R, Alam R, Broide DH, Wasserman SI, Weiskopf D, McKinney DM, Chung JL, Petersen A, Grey H, Peters B, Sette A.

 J Immunol.  2010
The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype.

Solomon C, Southwood S, Hoof I, Rudersdorf R, Peters B, Sidney J, Pinilla C, Marcondes MC, Ling B, Marx P, Sette A, Mothé BR.  Immunogenetics.  2010
Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage.

Kotturi MF, Botten J, Maybeno M, Sidney J, Glenn J, Bui HH, Oseroff C, Crotty S, Peters B, Grey H, Altmann DM, Buchmeier MJ, Sette A.  Immunome Res.  2010
Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus.
 
Alexander J, Bilsel P, del Guercio MF, Marinkovic-Petrovic A, Southwood S, Stewart S, Ishioka G, Kotturi MF, Botten J, Sidney J, Newman M, Sette A.  Hum Immunol.  2010
Design and utilization of epitope-based databases and predictive tools.

Salimi N, Fleri W, Peters B, Sette A.  Immunogenetics.  2010
TiArA: a virtual appliance for the analysis of Tiling Array data.

Greenbaum JA, Assarsson E, Chung JL, Head S, Sette A, Peters B.  PLoS One.  2010
Five HLA-DP molecules frequently expressed in the worldwide human population share a common HLA supertypic binding specificity.

Sidney J, Steen A, Moore C, Ngo S, Chung J, Peters B, Sette A.  J Immunol.  2010
Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.

Moutaftsi M, Tscharke DC, Vaughan K, Koelle DM, Stern L, Calvo-Calle M, Ennis F, Terajima M, Sutter G, Crotty S, Drexler I, Franchini G, Yewdell JW, Head SR, Blum J, Peters B, Sette A.  Future Microbiol.  2010
Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101.

Oswald-Richter K, Sato H, Hajizadeh R, Shepherd BE, Sidney J, Sette A, Newman LS, Drake WP.  J Clin Immunol.  2010
Universal influenza DNA vaccine encoding conserved CD4+ T cell epitopes protects against lethal viral challenge in HLA-DR transgenic mice.
 
Alexander J, Bilsel P, del Guercio MF, Stewart S, Marinkovic-Petrovic A, Southwood S, Crimi C, Vang L, Walker L, Ishioka G, Chitnis V, Sette A, Assarsson E, Hannaman D, Botten J, Newman MJ.  Vaccine.  2010
The immune epitope database 2.0.

Vita R, Zarebski L, Greenbaum JA, Emami H, Hoof I, Salimi N, Damle R, Sette A, Peters B.  Nucleic Acids Res.  2010
Definition of epitopes and antigens recognized by vaccinia specific immune responses: their conservation in variola virus sequences, and use as a model system to study complex pathogens.
 
Sette A, Grey H, Oseroff C, Peters B, Moutaftsi M, Crotty S, Assarsson E, Greenbaum J, Kim Y, Kolla R, Tscharke D, Koelle D, Johnson RP, Blum J, Head S, Sidney J.  Vaccine.  2009
The smallpox vaccine induces an early neutralizing IgM response.
 
Moyron-Quiroz JE, McCausland MM, Kageyama R, Sette A, Crotty S.  Vaccine.  2009
A multivalent and cross-protective vaccine strategy against arenaviruses associated with human disease.

Kotturi MF, Botten J, Sidney J, Bui HH, Giancola L, Maybeno M, Babin J, Oseroff C, Pasquetto V, Greenbaum JA, Peters B, Ting J, Do D, Vang L, Alexander J, Grey H, Buchmeier MJ, Sette A.  PLoS Pathog.  2009
Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population.

Greenbaum JA, Kotturi MF, Kim Y, Oseroff C, Vaughan K, Salimi N, Vita R, Ponomarenko J, Scheuermann RH, Sette A, Peters B.  Proc Nat Acad Sci USA.  2009
Design and preclinical development of a recombinant protein and DNA plasmid mixed format vaccine to deliver HIV-derived T-lymphocyte epitopes.

Walker LE, Vang L, Shen X, Livingston BD, Post P, Sette A, Godin CS, Newman MJ.  Vaccine.  2009
P17-24. Interfering overlapping epitopes contribute to the subdominance of an HLA-A2-restricted HIV Gag-specific epitope.

Kan-Mitchell J, Nyakeriga AM, Salkowitz JR, Costanzo MC, Sidney J, Sette A, Ayyavoo V.  J Immunol.
2009
Quantitating T cell cross-reactivity for unrelated peptide antigens.
 
Ishizuka J, Grebe K, Shenderov E, Peters B, Chen Q, Peng Y, Wang L, Dong T, Pasquetto V, Oseroff C, Sidney J, Hickman H, Cerundolo V, Sette A, Bennink JR, McMichael A, Yewdell JW.  J Immunol.  2009
Classification of the universe of immune epitope literature: representation and knowledge gaps.
 
Davies V, Vaughan K, Damle R, Peters B, Sette A.  PLoS One.  2009
Diverse recognition of conserved orthopoxvirus CD8+ T cell epitopes in vaccinated rhesus macaques.
Walsh SR, Gillis J, Peters B, Mothé BR, Sidney J, Sette A, Johnson RP.  Vaccine.
2009
Cellular immune response to cryptic epitopes during therapeutic gene transfer.  Li C, Goudy K, Hirsch M, Asokan A, Fan Y, Alexander J, Sun J, Monahan P, Seiber D, Sidney J, Sette A, Tisch R, Frelinger J, Samulski RJ.  Proc Natl Acad Sci USA.  2009
Of mice and humans: how good are HLA transgenic mice as a model of human immune responses?

Kotturi MF, Assarsson E, Peters B, Grey H, Oseroff C, Pasquetto V, Sette A.  Immunome Res.  2009
Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity.

Loffredo JT, Sidney J, Bean AT, Beal DR, Bardet W, Wahl A, Hawkins OE, Piaskowski S, Wilson NA, Hildebrand WH, Watkins DI, Sette A.  J Immunol.  2009
Herpes simplex virus type 2 tegument proteins contain subdominant T-cell epitopes detectable in BALB/c mice after DNA immunization and infection.

Muller WJ, Dong L, Vilalta A, Byrd B, Wilhelm KM, McClurkan CL, Margalith M, Liu C, Kaslow D, Sidney J, Sette A, Koelle DM.  J Gen Virol.  2009
A protective role for dengue virus-specific CD8+ T cells.  Yauch LE, Zellweger RM, Kotturi MF, Qutubuddin A, Sidney J, Peters B, Prestwood TR, Sette A, Shresta S.  J Immunol.  2009
Intestinal T cell responses to gluten peptides are largely heterogeneous: implications for a peptide-based therapy in celiac disease.
 
Camarca A, Anderson RP, Mamone G, Fierro O, Facchiano A, Costantini S, Zanzi D, Sidney J, Auricchio S, Sette A, Troncone R, Gianfrani C.  J Immunol.  2009
Correlates of protection efficacy induced by vaccinia virus-specific CD8(+) T-cell epitopes in the murine intranasal challenge model.

Moutaftsi M, Salek-Ardakani S, Croft M, Peters B, Sidney J, Grey H, Sette A. 
Eur J Immunol.
2009 
Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells.
 
Salek-Ardakani S, Arens R, Flynn R, Sette A, Schoenberger SP, Croft M.  J Immunol.  2009

Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues.

Vaughan K, Blythe M, Greenbaum J, Zhang Q, Peters B, Doolan DL, Sette A.
Parasite Immunol. 2009
NetMHCpan, A method for MHC class I binding prediction beyond humans.

Hoof I, Peters B, Sidney J, Pedersen LE, Sette A, Lund O, Buus S, Nielsen M.  Immunogenetics.  2009

HLA class I supertypes: a revised and updated classification.

Sidney J, Peters B, Frahm N, Brander C, Sette A.  BMC Immunol.  2008
Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. Sette A, Moutaftsi M, Moyron-Quiroz J, McCausland MM, Davies DH, Johnston RJ, Peters B, Rafii-El-Idrissi Benhnia M, Hoffmann J, Su HP, Singh K, Garboczi DN, Head S, Grey H, Felgner PL, Crotty S.  Immunity
2008

Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserve.

Oseroff C, Peters B, Pasquetto V, Moutaftsi M, Sidney J, Panchanathan V, Tscharke DC, Maillere B, Grey H, Sette A. J Immunol.  2008

Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance. 

Dow C, Oseroff C, Peters B, Nance-Sotelo C, Sidney J, Buchmeier M, Sette A, Mothé BR.  J Virol.  2008

Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses.

Dow C, Oseroff C, Peters B, Nance-Sotelo C, Sidney J, Buchmeier M, Sette A, Mothé BR.  J Virol.
2008
Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes.
Assarsson E, Greenbaum JA, Sundström M, Schaffer L, Hammond JA, Pasquetto V, Oseroff C, Hendrickson RC, Lefkowitz EJ, Tscharke DC, Sidney J, Grey HM, Head SR, Peters B, Sette A.  Proc Natl Acad Sci U S A.  2008

Immunomic Analysis of the Repertoire of T cell Specificities for Influenza A Virus in Humans. 

Assarsson E, Bui HH, Sidney J, Zhang Q, Glenn J, Oseroff C, Mbawuike IN, Alexander J, Newman MJ, Grey H, Sette A.  J Virol.
2008

Characterization of the peptide-binding specificity of the chimpanzee class I alleles A 0301 and A 0401 using a combinatorial peptide library.

Sidney J, Peters B, Moore C, Pencille TJ, Ngo S, Masterman KA, Asabe S, Pinilla C, Chisari FV, Sette A.  Immunogenetics.  2007

Immune epitope mapping in the post-genomic era: lessons for vaccine development. 

Sette A, Peters B.  Curr Opin Immunol.  2007
Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection.  Rawson PM, Molette C, Videtta M, Altieri L, Franceschini D, Donato T, Finocchi L, Propato A, Paroli M, Meloni F, Mastroianni CM, d'Ettorre G, Sidney J, Sette A, Barnaba V.  Nat Med.  2007

Integrating epitope data into the emerging web of biomedical knowledge resources. 

Peters B, Sette A.  Nat Rev Immunol.  2007

Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses. 

Moutaftsi M, Bui HH, Peters B, Sidney J, Salek-Ardakani S, Oseroff C, Pasquetto V, Crotty S, Croft M, Lefkowitz EJ, Grey H, Sette A.  J Immunol.  2007

Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes. 

Mothé BR, Stewart BS, Oseroff C, Bui HH, Stogiera S, Garcia Z, Dow C, Rodriguez-Carreno MP, Kotturi M, Pasquetto V, Botten J, Crotty S, Janssen E, Buchmeier MJ, Sette A.  J Immunol.  2007

The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus. 

Kotturi MF, Peters B, Buendia-Laysa F Jr, Sidney J, Oseroff C, Botten J, Grey H, Buchmeier MJ, Sette A.  J Virol.  2007

Ab and T cell epitopes of influenza A virus, knowledge and opportunities.

Bui HH, Peters B, Assarsson E, Mbawuike I, Sette A.  Proc Natl Acad Sci U S A.  2007

A quantitative analysis of the variables affecting the repertoire of T cell specificities recognized after vaccinia virus infection. 

Assarsson E, Sidney J, Oseroff C, Pasquetto V, Bui HH, Frahm N, Brander C, Peters B, Grey H, Sette A.  J Immunol.
2007

A community resource benchmarking predictions of peptide binding to MHC-I molecules.
 

Peters B, Bui HH, Frankild S, Nielson M, Lundegaard C, Kostem E, Basch D, Lamberth K, Harndahl M, Fleri W, Wilson SS, Sidney J, Lund O, Buus S, Sette A.  PLoS Comput Biol.  2006
A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus.  Moutaftsi M, Peters B, Pasquetto V, Tscharke DC, Sidney J, Bui HH, Grey H, Sette A.  Nat Biotechnol.  2006